PNP Biotech Inc
NMN
Quick Details
What is NMN ?
1)NMN zwitterion is a nicotinamide mononucleotide. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate base of a NMN(+). It is a conjugate acid of a NMN(-).
2)Nicotinamide ribotide is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
3)Nicotinamide mononucleotide is a natural product found in Drosophila melanogaster, Homo sapiens, and other organisms with data available.
Product Applications
1) Improves Brain Function
Perhaps one of the most devastating age-related diseases is Alzheimer’s disease, whereby the afflicted are robbed of their memories. NMN has been shown to improve cognition in rodents with Alzheimer’s and reduce brain plaques and neurodegenration in Alzheimer’s mice. While Alzheimer’s is an end-stage disease, many older adults also suffer from cognitive impairments — inability to learn, remember, and think properly. These age-related cognitive impairments have been prevented by NMN in mice. Cognitive impairments are sometimes associated with depression, which has also been shown to be alleviated by NMN in mice.
2) Restores Blood Vessel Health
Our blood vessels transport vital nutrients to each of our cells. As we age, our blood vessels become rigid and more susceptible to blockage, which can lead to heart attack or stroke. NMN has been shown to reverse vascular aging by restoring blood vessel elasticity in mice. Senescent cells — growth arrested cells that accumulate with aging — contribute to the aging of many organ systems, including the vascular system. In mice, NMN stops blood vessel aging my reducing senescent cells, leading to alleviation of hypertension. One of the ways senescent cells contribute to aging is by promoting inflammation, which underlies nearly every age-related disease. NMN has been shown to reverse blood vessel dysfunction by reducing blood vessel inflammation in mice.
3)Improves Muscle Function
We rely on our skeletal muscles for movement, stability, and strength. As we age, our muscles lose their ability to regenerate and grow, leading to the age-related decline in muscle strength and size called sarcopenia. Along with muscle weakness, we also become more fatigued and have less physical endurance. NMN seems to reverse these conditions, as one of its transporters has been shown to increase strength and physical endurance in mice. Furthermore, NMN improves muscle strength and performance in older men, and enhances oxygen utilization and exercise endurance in middle-aged runners. On the other hand, another NAD+ precursor called nicotinamide riboside (NR) does seem to improve muscle function.
4)Protects Against Obesity and Diabetes
Obesity is linked to a wide array of metabolic deficiencies, including insulin resistance — when are cells cannot utilize glucose due to impaired insulin signaling — which can lead to diabetes. Mitochondria are the final cellular destination for the food we eat to be converted into energy, making them of key importance in metabolism and related diseases. NMN has been shown to double the amount mitochondria in the livers of obese mice, which could protect against obesity. Stimulating fat breakdown with NMN could also help obese individuals lose fat. Furthermore, NMN improves the metabolism and health of mice born to obese mothers.
- Form :
- Powder
- CAS. NO:
- 1094-61-7
